The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice.

نویسندگان

  • Giovanni Delogu
  • Maurizio Sanguinetti
  • Brunella Posteraro
  • Stefano Rocca
  • Stefania Zanetti
  • Giovanni Fadda
چکیده

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

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عنوان ژورنال:
  • Infection and immunity

دوره 74 5  شماره 

صفحات  -

تاریخ انتشار 2006